Forcing contact inhibition of locomotion
نویسندگان
چکیده
Contact inhibition of locomotion drives a variety of biological phenomenon, from cell dispersion to collective cell migration and cancer invasion. New imaging techniques have allowed contact inhibition of locomotion to be visualised in vivo for the first time, helping to elucidate some of the molecules and forces involved in this phenomenon.
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Regulation of contact inhibition of locomotion by Eph–ephrin signalling
Contact inhibition of locomotion (CIL) occurs when a cell stops migrating in a particular direction upon contact with another cell. Many cancer cells show Contact inhibition of locomotion when contacting one another but display contact-unimpeded migration following collision with noncancer cells. Here we review current understanding of Contact inhibition of locomotion, from Abercrombie's histor...
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Masamitsu Tanaka*, Sei Kuriyama and Namiko Aiba From the Department of Molecular Medicine and Biochemistry, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan Running Title: Nm23H1 regulates contact inhibition of locomotion *Address correspondence to: Masamitsu Tanaka, Tel. +81-018-884-6077; Fax. +81-018-884-6078; E-mail address: [email protected] Abbrevia...
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